反应详情

n-Propyl isocyanate (86 μL, 0.922 mmol) was added to a slurry of 4-[(4-amino-2-ethyl-2H-pyrazolo[3,4-c]quinolin-1-yl)methyl]piperidin-4-ol (0.300 g, 0.922 mmol) in chloroform (10 mL). After 16 hours, the solution was purified via automated flash chromatography eluting with a linear gradient of 2-25% CMA in chloroform. The residue was triturated in acetonitrile and isolated by filtration to provide 0.277 g of 4-[(4-amino-2-ethyl-2H-pyrazolo[3,4-c]quinolin-1-yl)methyl]-4-hydroxy-N-propylpiperidine-1-carboxamide as a flocculent white solid, mp 208.5-210° C.

1. customthe solution was purified via automated flash chromatography
2. washeluting with a linear gradient of 2-25% CMA in chloroform
3. customThe residue was triturated in acetonitrile
4. customisolated by filtration