Hydrochloric Acid → HCID 67158816, compound

Participants

Reaction Conditions

Reaction Steps

Hydrochloric acid (3.9 mL of 6 M) was added to a solution of tert-butyl 4-[(4-bromo-5-cyano-2-propyl-2H-pyrazol-3-yl)methyl]-4-fluoropiperidine-1-carboxylate (3.34 g, 7.78 mmol) in ethanol (40 mL), and the reaction was heated at 70° C. for 1.5 hours, allowed to cool to room temperature, and concentrated under reduced pressure to provide 2.9 g of 4-bromo-5-[(4-fluoropiperidin-4-yl)methyl]-1-propyl-1H-pyrazole-3-carbonitrile hydrochloride. The salt was suspended in dichloromethane (40 mL), and triethylamine (4.9 mL, 4.5 eq.) was added. The mixture was stirred for ten minutes to provide a 0.2 M solution of 4-bromo-5-[(4-fluoropiperidin-4-yl)methyl]-1-propyl-1H-pyrazole-3-carbonitrile.

Provenance & Evidence