Piperazine → HCID 10430452, compound

Participants

Reaction Steps

A solution of 6-benzenesulfonyl-4-chloro-quinoline (35 mg, 0.11 mmol) and piperazine (0.5 g, 2.5 mmol) in acetonitrile (2 mL) was heated at 80° C. over night. The mixture was extracted with toluene and water. The organic phase was purified by chromatography on silica gel eluted with CHCl3 saturated with NH3 (gas). The pure product was dissolved in ethyl acetate and HCl (gas) in diethyl ether was added. The resulting oily residue was dissolved in methanol and ethyl acetate and evaporated to yield a white solid (24 mg, 77%). MS m/z: 354 [M+H+]. 1H NMR (270 MHz, CH3OH-D4) δ ppm 3.52 (m, 4H) 4.13 (m, 4H) 7.36 (d, J=7.18 Hz, 1H) 7.57 (m, 3H) 8.01 (m, J=12.25, 8.54 Hz, 3H) 8.28 (d, J=8.91 Hz, 1H) 8.63 (d, J=6.68 Hz, 1H) 8.69 (s, 1H).

Provenance & Evidence