3-Chloro-2-methylbenzenesulfonyl chloride → 1-(3-Chloro-2-methyl-benzenesulfonyl)-4-piperazin-1-yl-1H-pyrrolo[3,2-c]pyridine Hydrochloride

HRID 549309Notes

Reaction equation

HRID 549309 reaction equation
[Cl:1][C:2]1[C:3]([CH3:12])=[C:4]([S:8](Cl)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[NH:13]1[C:21]2[CH:20]=[CH:19][N:18]=[C:17]([N:22]3[CH2:27][CH2:26][N:25](C(OC(C)(C)C)=O)[CH2:24][CH2:23]3)[C:16]=2[CH:15]=[CH:14]1>>[ClH:1].[Cl:1][C:2]1[C:3]([CH3:12])=[C:4]([S:8]([N:13]2[C:21]3[CH:20]=[CH:19][N:18]=[C:17]([N:22]4[CH2:23][CH2:24][NH:25][CH2:26][CH2:27]4)[C:16]=3[CH:15]=[CH:14]2)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 5227343-Chloro-2-methylbenzenesulfonyl chlorideHCID 671567091-Piperazinecarboxylic acid,4-(1h-pyrrolo[3,2-c]pyridin-4-yl)-,1,1-dimethylethyl ester

Product 1

HCID 671575911-(3-Chloro-2-methyl-benzenesulfonyl)-4-piperazin-1-yl-1H-pyrrolo[3,2-c]pyridine Hydrochloride

Procedure

3-Chloro-2-methylbenzenesulfonyl chloride (29.0 mg) was added to tert-butyl 4-(1H-pyrrolo[3,2-c]pyridin-4-yl)piperazine-1-carboxylate the title compound (6.3 mg). LC/MS RT: 1.563 (System 10 till 40% MeCN over 1.5 min, ACE C8), Purity. 96%. MS: 392 (M+1).

Sources & evidence

ORD record
ord-055ff6689da64e23a02a1c5460567649
Source dataset
uspto-grants-2011_05
Patent number
US07943639B2

Reaction notes

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