Dicyclohexylcarbodiimide → HCID 86629000, compound

HRID 549322Notes

Reaction equation

HRID 549322 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][C:15]([OH:17])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2NN=[N:27][N:26]=2)=[CH:21][CH:20]=1.C1(N=C=NC2CCCCC2)CCCCC1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][C:15]1[O:17][C:25]([C:22]2[CH:23]=[CH:24][C:19]([F:18])=[CH:20][CH:21]=2)=[N:26][N:27]=1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 50585361-Boc-2-Piperidineacetic AcidHCID 178505596HCID 178505596, compound

Product 1

HCID 86629000HCID 86629000, compoundYield 74.2%

Procedure

The title compound (1.34 g) was prepared from 2-carboxymethyl-piperidine-1-carboxylic acid tert butyl ester (1.22 g), 5-(4-fluorophenyl)tetrazole (0.82 g) and dicyclohexylcarbodiimide (1.05 g) according to the method of description 1.

Sources & evidence

ORD record
ord-51126d6ef0334e968e1e0250a191a059
Source dataset
uspto-grants-2011_05
Patent number
US07943645B2

Reaction notes

Loading…