Dicyclohexylcarbodiimide → HCID 86629001, compound

HRID 549323Notes

Reaction equation

HRID 549323 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][C:15]([OH:17])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2NN=[N:27][N:26]=2)=[CH:21][CH:20]=1.C1(N=C=NC2CCCCC2)CCCCC1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][C:15]1[O:17][C:25]([C:22]2[CH:23]=[CH:24][C:19]([Cl:18])=[CH:20][CH:21]=2)=[N:26][N:27]=1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 50585361-Boc-2-Piperidineacetic AcidHCID 178478003HCID 178478003, compound

Product 1

HCID 86629001HCID 86629001, compoundYield 84.3%

Procedure

The title compound (1.65 g) was prepared from 2-carboxymethyl-piperidine-1-carboxylic acid tert butyl ester (1.26 g), 5-(4-chlorophenyl)tetrazole (1.08 g) and dicyclohexylcarbodiimide (1.15 g) according to the method of description 1.

Sources & evidence

ORD record
ord-196fb5f5e8064277b5aa26ad7d2ea183
Source dataset
uspto-grants-2011_05
Patent number
US07943645B2

Reaction notes

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