HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-1-(4-fluorophenyl)ethan-1-one → (S)-2-[2-(4-Fluoro-phenyl)-2-oxo-ethoxycarbonylmethyl]-pyrrolidine-1-carboxylic tert butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-1-(4-fluorophenyl)ethan-1-one | HCID 96749 | — |
| Reactant | (S)-2-(1-BOC-2-pyrrolidinyl)acetic acid | HCID 688605 | — |
| Product | (S)-2-[2-(4-Fluoro-phenyl)-2-oxo-ethoxycarbonylmethyl]-pyrrolidine-1-carboxylic tert butyl ester | HCID 86629008 | 99.5% |
Reaction Steps
The title compound (3.2 g) was prepared from (S)-2-carboxymethyl-pyrrolidine-1-carboxylic acid tert butyl ester (2.02 g) and 2-bromo-4′-fluoroacetophenone (1.91 g) according to the method of description 36.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07943645B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-e6e0a3032d1c4193a10771658601bedb |
| Source note | uspto-grants-2011_05 |