HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 54934Generated: October 29, 2026
Hydrochloric Acid → 3-(4-Fluorophenyl)-3-oxo-2-(4-pyridinyl)propanenitrile
https://huagongshe.com/reaction/54934
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 5-(4-Fluorophenyl)-4-(pyridin-4-yl)isoxazole | HCID 22909012 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 3-(4-Fluorophenyl)-3-oxo-2-(4-pyridinyl)propanenitrile | HCID 18625655 | 98.5% |
Reaction Steps
A suspension of 5-(4-fluorophenyl)-4-(pyridin-4-yl)isoxazole (5.35 g) in 1N sodium hydroxide aqueous solution (50 ml) was stirred for one hour at 60° C. The solution was cooled and adjusted to pH 6 with concentrated hydrochloric acid. The separated solid was collected, washed with water, and dried to give 3-(4-fluorophenyl)-3-oxo-2-(pyridin-4-yl)propanenitrile (5.27 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05624931 |
|---|
| Source dataset | uspto-grants-1997_04 |
|---|
| ORD ID | ord-9fb4a1b220d1432b808747deaced1f8d |
|---|
| Source note | uspto-grants-1997_04 |
|---|
