反应详情

A mixture of 2-(4-fluorophenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine (56 mg) and sodium borohydride (16 mg) in ethanol (2 ml) was refluxed for 2 hours, cooled, and poured into ice water. The separated oil was extracted with dichloromethane. The extract was washed with brine, dried and concentrated in vacuo. The residue was crystallized from a mixture of ethyl acetate and ethyl ether to yield 2-(4-fluorophenyl)-3-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine (44 mg).

1. temperaturewas refluxed for 2 hours
2. temperaturecooled
3. extractionThe separated oil was extracted with dichloromethane
4. washThe extract was washed with brine
5. customdried
6. concentrationconcentrated in vacuo
7. customThe residue was crystallized from a mixture of ethyl acetate and ethyl ether