Hydrochloric Acid → HCID 44236213, compound

Participants

Reaction Steps

A solution of 3-[4-((E)-2-hydroxycarbamoyl-vinyl)-phenyl]-4-[2-(2-methyl-1H-indol-3-yl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester (55.8 mg, 0.111 mmol) in dioxane (5 mL) was treated with a solution of hydrochloric acid in dioxane (0.03 mL, 4 M) and the resulting mixture was stirred at room temperature. A brown precipitate was collected and dissolved in water. The aqueous solution was washed with diethyl ether and concentrated to give (E)-N-hydroxy-3-(4-{1-[2-(2-methyl-1H-indol-3-yl)-ethyl]-piperazin-2-yl}-phenyl)-acrylamide (89, 49 mg, 99% yield). LCMS (m/z): 405.1 (M+1).

Provenance & Evidence