HCID 57899288, compound → HCID 57899289, compound

Participants

Reaction Steps

(R)-2-[4-((E)-2-Methoxycarbonyl-vinyl)-phenyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (2.4 g, 7.242 mmol) was dissolved in ethanol (100 mL), and wet 10% Pd/C added. The reaction mixture was placed under an atmosphere of hydrogen for 4 hrs (Parr apparatus, 25 psi) then filtered through a plug of celite and concentrated to dryness to give (R)-2-[4-(2-methoxycarbonyl-ethyl)-phenyl]-pyrrolidine-1-carboxylic acid tert-butyl ester as a colorless oil (2.4 g, 7.2 mmol, >99% yield).

Provenance & Evidence