HCID 57737267, compound → HCID 178457633, compound

HRID 549434Notes

Reaction equation

HRID 549434 reaction equation
C(OC([N:6]1[C:10]2[S:11][C:12]([C:14](=[O:25])[NH:15][C:16]([CH3:24])([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH3:17])=[CH:13][C:9]=2[C:8]([NH:26][C:27](=[O:42])[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=2[NH:34][C:35]([C:37]2[NH:38][CH:39]=[CH:40][CH:41]=2)=[O:36])=[N:7]1)=O)C>CO>[CH3:24][C:16]([NH:15][C:14]([C:12]1[S:11][C:10]2[NH:6][N:7]=[C:8]([NH:26][C:27](=[O:42])[C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[NH:34][C:35]([C:37]3[NH:38][CH:39]=[CH:40][CH:41]=3)=[O:36])[C:9]=2[CH:13]=1)=[O:25])([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH3:17]

Participants

3

Reactant 1

HCID 57737267HCID 57737267, compound

Product 1

HCID 178457633HCID 178457633, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5-(1-Methyl-1-phenyl-ethylcarbamoyl)-3-{2-[(1H-pyrrole-2-carbonyl)amino]benzoylamino}-thieno[2,3-c]pyrazole-1-carboxylic acid ethyl ester as crude from the previous reaction was treated with a 10% solution of TEA in methanol (25 mL) overnight. The solvent was evaporated under vacuum and the product was purified by flash chromatography (eluant dichloromethane/methanol 97/3) (78.5 mg, 36%),

Workup

  1. customThe solvent was evaporated under vacuum
  2. customthe product was purified by flash chromatography (eluant dichloromethane/methanol 97/3) (78.5 mg, 36%)

Sources & evidence

ORD record
ord-6271d30a3e2c498383b4e776be042e23
Source dataset
uspto-grants-2011_05
Patent number
US07943654B2

Reaction notes

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