Methyl iodide → HCID 25174277, compound

Participants

Reaction Steps

To a mixture of Example 2 N-(6-cyano-2,2-dimethyl-2,3-dihydro-1H-inden-1-yl)-5-chloro-1H-indole-2-carboxamide (30 mg, 0.083 mmol) and K2CO3 (34 mg, 2.48 mmol) in DMF (0.3 mL) was added methyl iodide (6 μL, 0.091 mmol) and the resulting mixture was stirred at rt for 16 h. Water (˜5 mL) was added dropwise followed by stirring for an additional 30 min. The precipitated solid was collected by vacuum filtration, rinsed with additional water (˜5 mL) and dried in vacuo to afford the title product as a white solid (26 mg). HPLC Ret. time: 3.79 min. LCMS MH+ (m/z) 378.30. 1H NMR: (DMSO-d6, 400 MHz): 8.72 (d, 1H), 7.71 (s, 1H), 7.68 (d, 1H), 7.65 (s, 1H), 7.58 (d, 1 H), 7.44 (d, 1 H), 7.26 (dd, 1 H), 7.18 (s, 1H), 5.34 (d, 1H), 4.00 (s, 3H), 2.52-2.48 (m, 2 H), 1.21 (s, 3H), 0.95 (s, 3H).

Provenance & Evidence