2',4'-Dihydroxyacetophenone → 2'-Hydroxy-4'-(ethoxycarbonyldimethylmethoxy)acetophenone

Participants

Reaction Steps

This compound was synthesized from 2′,4′-dihydroxyacetophenone and ethyl bromoisobutyrate (1 eq) according to general method 4 described earlier. It was purified by chromatography on silica gel (elution:cyclohexane/ethyl acetate 9:1). 1H NMR CDCl3 δppm: 1.25 (t, J=7.17 Hz, 3H), 1.67 (s, 6H), 2.56 (s, 3H), 4.24 (q, J=7.17 Hz, 2H), 6.27 (d, J=2.55 Hz, 1H), 6.37 (dd, J=2.55 Hz, J=8.72 Hz, 1H), 7.62 (d, J=8.72 Hz, 1H), 12.6 (signal, 1H).

Provenance & Evidence