HCID 178440597, compound → HCID 178458987, compound

HRID 549507Notes

Reaction equation

HRID 549507 reaction equation
[Si]([O:8][C:9]([CH3:45])([CH3:44])[CH2:10][C:11]1[CH:12]=[CH:13][C:14]2[C:27]3[N:26]=[C:25]([C:28]4[C:33]([Br:34])=[CH:32][CH:31]=[CH:30][C:29]=4[Br:35])[NH:24][C:23]=3[C:22]3[C:17](=[CH:18][C:19]([O:36][CH2:37][CH2:38][CH2:39][C:40]([F:43])([F:42])[F:41])=[CH:20][CH:21]=3)[C:15]=2[CH:16]=1)(C(C)(C)C)(C)C.[Si](OC(C)(C)CC1C=CC2C3N=C(C4C(Br)=CC=CC=4Br)NC=3C3C(=CC(OCC4CC4)=CC=3)C=2C=1)(C(C)(C)C)(C)C>>[Br:35][C:29]1[CH:30]=[CH:31][CH:32]=[C:33]([Br:34])[C:28]=1[C:25]1[NH:24][C:23]2[C:22]3[C:17]([C:15]4[CH:16]=[C:11]([CH2:10][C:9]([CH3:45])([OH:8])[CH3:44])[CH:12]=[CH:13][C:14]=4[C:27]=2[N:26]=1)=[CH:18][C:19]([O:36][CH2:37][CH2:38][CH2:39][C:40]([F:43])([F:41])[F:42])=[CH:20][CH:21]=3

Participants

3

Reactant 2

HCID 178440597HCID 178440597, compoundHCID 178440599HCID 178440599, compound

Product 1

HCID 178458987HCID 178458987, compound

Procedure

This imidazole was prepared as described in Step 8 of Route A of Example 168, substituting 6-(2-([tert-butyl(dimethyl)silyl]oxy)-2-methylpropyl)-2-(2,6-dibromophenyl)-9-(4,4,4-trifluorobutoxy)-1H-phenanthro[9,10-d]imidazole from Step 5 above for 6-(2-{[tert-butyl(dimethyl)silyl]oxy}-2-methylpropyl)-9-(cyclopropylmethoxy)-2-(2,6-dibromophenyl)-1H-phenanthro[9,10-d]imidazole.

Sources & evidence

ORD record
ord-feee29259b3248019a0414f6537df9bf
Source dataset
uspto-grants-2011_05
Patent number
US07943649B2

Reaction notes

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