反应详情

A mixture of 3-(4-fluorophenyl)-2-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine (100 mg), triethylamine (0.4 ml) and acetic anhydride (0.2 ml) in dry 1,2-dichloroethane (3 ml) was refluxed for 2 days. The reaction mixture was cooled and concentrated in vacuo. The residue was dissolved in dichloromethane and the solution was washed with an aqueous saturated sodium bicarbonate solution and brine, dried and concentrated in vacuo. The residue was purified by column chromatography on silica gel and the obtained oil was crystallized from diisopropyl ether to give 4-acetyl-3-(4-fluorophenyl)-2-(pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine (60 mg).

1. temperaturewas refluxed for 2 days
2. temperatureThe reaction mixture was cooled
3. concentrationconcentrated in vacuo
4. dissolutionThe residue was dissolved in dichloromethane
5. washthe solution was washed with an aqueous saturated sodium bicarbonate solution and brine
6. customdried
7. concentrationconcentrated in vacuo
8. customThe residue was purified by column chromatography on silica gel
9. customthe obtained oil was crystallized from diisopropyl ether