反应详情

A mixture of 8-(4-fluorophenyl)-4-methyl-7-(pyridin-4-yl)pyrazolo[5,1-c][1,2,4]triazine (53 mg) and sodium borohydride (13 mg) in ethanol (1 ml) was refluxed for 3 hours, cooled and poured into ice-water. The separated oil was extracted with dichloromethane. The extract was washed with brine, dried and concentrated in vacuo. The residue was purified by column chromatography on silica gel and the obtained oil was crystallized from diisopropyl ether to give 1,4-dihydro-8-(4-fluorophenyl)-4-methyl-7-(pyridin-4-yl)pyrazolo[5,1-c][1,2,4]triazine (13 mg).

1. temperaturewas refluxed for 3 hours
2. temperaturecooled
3. extractionThe separated oil was extracted with dichloromethane
4. washThe extract was washed with brine
5. customdried
6. concentrationconcentrated in vacuo
7. customThe residue was purified by column chromatography on silica gel
8. customthe obtained oil was crystallized from diisopropyl ether