L-Prolinamide → 1-{[3-(4-{[4-[5-Fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)phenyl]carbonyl}-L-prolinamide

Participants

Role	Name	HCID	Charge
Reactant	L-Prolinamide	HCID 111306	—
Reactant	3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)benzoic acid	HCID 25180783	—
Product	1-{[3-(4-{[4-[5-Fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)phenyl]carbonyl}-L-prolinamide	HCID 24782413	—

Reaction Steps

Prepared similarly to Example 1 from 3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)benzoic acid and L-prolinamide with System A used for purification by mass directed autopreparation

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07943651B2
Source dataset	uspto-grants-2011_05
ORD ID	ord-ef806b0a32964a34a5cea91fa21cdd8a
Source note	uspto-grants-2011_05