L-Serinamide → HCID 24782415, compound

HRID 549533Notes

Reaction equation

HRID 549533 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:39][CH3:40])=[C:6]([C:8]([CH3:38])([CH3:37])[CH2:9][C:10]([OH:36])([C:32]([F:35])([F:34])[F:33])[CH2:11][NH:12][C:13]2[CH:21]=[C:20]([CH3:22])[CH:19]=[C:18]3[C:14]=2[CH:15]=[N:16][N:17]3[C:23]2[CH:24]=[C:25]([CH:29]=[CH:30][CH:31]=2)[C:26]([OH:28])=O)[CH:7]=1.[NH2:41][C@H:42]([C:45]([NH2:47])=[O:46])[CH2:43][OH:44]>>[NH2:47][C:45](=[O:46])[C@@H:42]([NH:41][C:26](=[O:28])[C:25]1[CH:29]=[CH:30][CH:31]=[C:23]([N:17]2[C:18]3[C:14](=[C:13]([NH:12][CH2:11][C:10]([OH:36])([C:32]([F:33])([F:35])[F:34])[CH2:9][C:8]([C:6]4[CH:7]=[C:2]([F:1])[CH:3]=[CH:4][C:5]=4[O:39][CH3:40])([CH3:38])[CH3:37])[CH:21]=[C:20]([CH3:22])[CH:19]=3)[CH:15]=[N:16]2)[CH:24]=1)[CH2:43][OH:44]

Participants

3

Reactant 2

HCID 101138L-SerinamideHCID 251807833-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)benzoic acid

Product 1

HCID 24782415HCID 24782415, compound

Procedure

Prepared similarly to Example 1 from 3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)benzoic acid and L-serinamide with System A used for purification by mass directed autopreparation.

Workup

  1. customused for purification by mass

Sources & evidence

ORD record
ord-5de1fcb3f5d247a489a4b3f8918ba5a8
Source dataset
uspto-grants-2011_05
Patent number
US07943651B2

Reaction notes

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