HRID549535

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID89675

2-Amino-N-methylacetamide

C3H8N2O

结构：COc1ccc(F)cc1C(C)(C)CC(O)(CNc1cc(C)cc2c1cnn2-c1cccc(C(=O)O)c1)C(F)(F)F

HCID25180783

未命名化合物

PRODUCTS

生成物

结构：CNC(=O)CNC(=O)c1cccc(-n2ncc3c(NCC(O)(CC(C)(C)c4cc(F)ccc4OC)C(F)(F)F)cc(C)cc32)c1

HCID24782662

未命名化合物

PROCEDURE

实验过程

Prepared similarly to Example 1 from 3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)benzoic acid and N1-methylglycinamide with System A used for purification by mass directed autopreparation.

WORKUP

后处理

customused for purification by mass

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-61857e0a4d5b4f6f9e5d9c0c17f3f3f5
来源数据集: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07943651B2
来源说明: uspto-grants-2011_05

反应 SMILES

[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:39][CH3:40])=[C:6]([C:8]([CH3:38])([CH3:37])[CH2:9][C:10]([OH:36])([C:32]([F:35])([F:34])[F:33])[CH2:11][NH:12][C:13]2[CH:21]=[C:20]([CH3:22])[CH:19]=[C:18]3[C:14]=2[CH:15]=[N:16][N:17]3[C:23]2[CH:24]=[C:25]([CH:29]=[CH:30][CH:31]=2)[C:26](O)=[O:27])[CH:7]=1.[CH3:41][NH:42][C:43](=[O:46])[CH2:44][NH2:45]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:39][CH3:40])=[C:6]([C:8]([CH3:37])([CH3:38])[CH2:9][C:10]([OH:36])([C:32]([F:34])([F:35])[F:33])[CH2:11][NH:12][C:13]2[CH:21]=[C:20]([CH3:22])[CH:19]=[C:18]3[C:14]=2[CH:15]=[N:16][N:17]3[C:23]2[CH:24]=[C:25]([CH:29]=[CH:30][CH:31]=2)[C:26]([NH:45][CH2:44][C:43]([NH:42][CH3:41])=[O:46])=[O:27])[CH:7]=1