2-amino-N-methylacetamide → HCID 24782662, compound

HRID 549535Notes

Reaction equation

HRID 549535 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:39][CH3:40])=[C:6]([C:8]([CH3:38])([CH3:37])[CH2:9][C:10]([OH:36])([C:32]([F:35])([F:34])[F:33])[CH2:11][NH:12][C:13]2[CH:21]=[C:20]([CH3:22])[CH:19]=[C:18]3[C:14]=2[CH:15]=[N:16][N:17]3[C:23]2[CH:24]=[C:25]([CH:29]=[CH:30][CH:31]=2)[C:26](O)=[O:27])[CH:7]=1.[CH3:41][NH:42][C:43](=[O:46])[CH2:44][NH2:45]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:39][CH3:40])=[C:6]([C:8]([CH3:37])([CH3:38])[CH2:9][C:10]([OH:36])([C:32]([F:34])([F:35])[F:33])[CH2:11][NH:12][C:13]2[CH:21]=[C:20]([CH3:22])[CH:19]=[C:18]3[C:14]=2[CH:15]=[N:16][N:17]3[C:23]2[CH:24]=[C:25]([CH:29]=[CH:30][CH:31]=2)[C:26]([NH:45][CH2:44][C:43]([NH:42][CH3:41])=[O:46])=[O:27])[CH:7]=1

Participants

3

Reactant 2

HCID 896752-amino-N-methylacetamideHCID 251807833-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)benzoic acid

Product 1

HCID 24782662HCID 24782662, compound

Procedure

Prepared similarly to Example 1 from 3-(4-{[4-[5-fluoro-2-(methyloxy)phenyl]-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)benzoic acid and N1-methylglycinamide with System A used for purification by mass directed autopreparation.

Workup

  1. customused for purification by mass

Sources & evidence

ORD record
ord-61857e0a4d5b4f6f9e5d9c0c17f3f3f5
Source dataset
uspto-grants-2011_05
Patent number
US07943651B2

Reaction notes

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