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1-Ethynyl-4-fluorobenzene → HCID 67169843、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Ethynyl-4-fluorobenzene | HCID 522627 | — |
| 反応物 | HCID 57791903 | HCID 57791903 | — |
| 反応物 | {4-[3-[2-(4-Chloro-phenyl)-ethoxy]-5-(4-hydroxymethyl-phenylethynyl)-phenylsulfanyl]-2-methylphenoxy}-acetic acid ethyl ester | HCID 67024299 | — |
| 生成物 | HCID 67169843 | HCID 67169843 | — |
反応手順
The title product was prepared from {4-[3-Bromo-5-(4-methanesulfonyl-benzyloxy)phenylsulfanyl]-2-methyl-phenoxy}-acetic acid ethyl ester (335 mg; 0.59 mmol), 1-ethynyl-4-fluorobenzene (142.3 mg; 1.19 mmol) applying the procedure described for {4-[3-[2-(4-Chloro-phenyl)-ethoxy]-5-(4-hydroxymethyl-phenylethynyl)-phenylsulfanyl]-2-methylphenoxy}-acetic acid ethyl ester. The crude product was purified by preparative HPLC (method B). Yield: 140 mg (39%). HPLC-MS: m/z: 605.5 (M+H)+; Rt: 2.80 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07943669B2 |
| 出典データセット | uspto-grants-2011_05 |
| ORD ID | ord-1c2e546b7a7942c395119cb8bf03e3e3 |
| 出典メモ | uspto-grants-2011_05 |