HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Benzoyl-4,5-dimethoxybenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 5,6-Dimethoxy-1,3-dihydro-2-benzofuran-1,3-dione | HCID 610356 | — |
| Reactant | HCID 178478979 | HCID 178478979 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Benzoyl-4,5-dimethoxybenzoic acid | HCID 19957159 | 74.9% |
Reaction Steps
Thirty grams (0.14 mole) of 4,5-dimethoxyphthalic anhydride was suspended in 300 mL of THF and 87 mL (0.17 mole) of phenylmagnesium chloride in THF was added over two hours. The reaction was stirred at room temperature for 14 hours, refluxed for two hours, cooled and poured into saturated ammonium chloride. The mixture was made acidic with 6N HCl, extracted into chloroform, dried over magnesium sulfate, concentrated to provide 30 g of 2-benzoyl-4,5-dimethoxybenzoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05624922 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-43f8f20b41bd492a896d88ca1f42014d |
| Source note | uspto-grants-1997_04 |