反应详情

Borane-THF complex (1.0 M solution in THF, 3.4 mL, 3.4 mmol) was added to a solution of tert-butyl 3-(pyridin-3-ylcarbamoyl)piperazine-1-carboxylate (522 mg, 1.70 mmol) in THF (4 mL). The reaction mixture was heated to reflux for 5 h. Upon cooling to rt, the reaction mixture was carefully quenched by the dropwise addition of MeOH. After gas evolution ceased, MeOH (10 mL) was added, and the reaction mixture was heated to reflux overnight. Upon cooling to rt, the reaction mixture was concentrated under reduced pressure, yielding the title compound which was used without further purification. LC-MS: RT=2.90 min, [M+H]+=293.1.

1. temperatureThe reaction mixture was heated
2. temperatureto reflux for 5 h
3. customthe reaction mixture was carefully quenched by the dropwise addition of MeOH
4. additionMeOH (10 mL) was added
5. temperaturethe reaction mixture was heated
6. temperatureto reflux overnight
7. temperatureUpon cooling to rt
8. concentrationthe reaction mixture was concentrated under reduced pressure