HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(4-nitrophenyl)-2-propenoate → Ethyl 3-(4-aminophenyl)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(4-nitrophenyl)-2-propenoate | HCID 95370 | — |
| Reactant | Ammonium formate | HCID 2723923 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 3-(4-aminophenyl)propanoate | HCID 10442595 | — |
Reaction Steps
The product was made by reducing ethyl 4-nitrocinnamate (110.6 g, 0.5 mol) with 10% palladium on Carbon (4.0 g) in 95% ethanol (2 L) in the presence of ammonium formate (126 g) to afford ethyl 3-(4-aminophenyl)propionate which was sulfonated with methanesulfonyl chloride in CH2Cl2 in the presence of pyridine to produce 102 g (75.2%) of N-[4-(ethoxycarbonylethyl)phenyl]methanesulfonamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05624922 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-9c407937a69a44a9adfc9992917e0aec |
| Source note | uspto-grants-1997_04 |