Trifluoroacetic acid → HCID 44140171, compound

Participants

Reaction Steps

To a stirred solution of tert-butyl 3-{[4-(3,4-dichlorophenyl)piperazin-1-yl]carbonyl}piperidine-1-carboxylate (1.002 g) in DCM (10 ml) was added TFA (10 ml). The reaction was allowed to stir at ambient temperature for 2 hours. The solvents were removed in vacuo, the residue partitioned between DCM and 2M NaOH, extracted twice and the combined organics dried (Na2SO4), filtered and evaporated to give the product, 1-(3,4-dichlorophenyl)-4-(piperidin-3-ylcarbonyl)piperazine, as a yellow foam (703 mg).

Provenance & Evidence