HCID 67158148, compound → HCID 67158734, compound

HRID 549933Notes

Reaction equation

HRID 549933 reaction equation
[CH:1]1([N:4]2[CH2:9][CH2:8][CH2:7][C@H:6]([CH2:10][N:11]3[CH2:16][CH2:15][N:14](C(OCC4C=CC=CC=4)=O)[CH2:13][CH2:12]3)[CH2:5]2)[CH2:3][CH2:2]1>C(O)C.[Pd]>[CH:1]1([N:4]2[CH2:9][CH2:8][CH2:7][C@H:6]([CH2:10][N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)[CH2:5]2)[CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 67158148HCID 67158148, compound

Product 1

HCID 67158734HCID 67158734, compoundYield 97.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Benzyl 4-{[(3R)-1-cyclopropylpiperidin-3-yl]methyl}piperazine-1-carboxylate (45 mg) was dissolved in ethanol (6 ml). 10% Palladium on carbon (Degussa) (72 mg) was added and the mixture stirred for 60 hours at room temperature under an atmosphere of hydrogen. A further amount of catalyst (60 mg) was added and the mixture stirred for 40 hours at room temperature under an atmosphere of hydrogen. The reaction mixture was filtered through a pad of Celite, washed with ethanol and the filtrate concentrated in vacuo to give the title compound as a white solid (27.5 mg).

Workup

  1. stirringthe mixture stirred for 40 hours at room temperature under an atmosphere of hydrogen
  2. filtrationThe reaction mixture was filtered through a pad of Celite
  3. washwashed with ethanol
  4. concentrationthe filtrate concentrated in vacuo

Sources & evidence

ORD record
ord-26e670476cc14cbb87b5520bf0cc2c01
Source dataset
uspto-grants-2011_05
Patent number
US07943768B2

Reaction notes

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