Methylhydrazine → 2-methyl-4-(4-pyridyl)-1-(2H)-phthalazinone

HRID 54994Notes

Reaction equation

HRID 54994 reaction equation
[C:1]([C:9]1[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=1[C:11](O)=[O:12])(=O)[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.[CH3:18][NH:19][NH2:20]>C1(C)C=CC=CC=1>[CH3:18][N:19]1[N:20]=[C:1]([C:2]2[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=2)[C:9]2[C:10](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:11]1=[O:12]

Participants

4

Reactant 2

HCID 6061MethylhydrazineHCID 103313122-(Isonicotinoyl)benzoic acid

Product 1

HCID 199571032-methyl-4-(4-pyridyl)-1-(2H)-phthalazinoneYield 81.2%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a suspension of 2-(isonicotinoyl)benzoic acid (10.0 g, 44.1 mmol) in toluene (50 mL) was added methyl hydrazine (2.59 mL, 48.6 mmol). The mixture was heated to reflux while collecting water in a Dean-Stark trap for 6 hours. Additional methylhydrazine (2.59 mL) was added and the mixture was heated to reflux for another 5 hours. The reaction mixture was cooled to room temperature and the product was collected by filtration. The product was recrystallized from hot methanol to afford 8.5 g (81%) of 2-methyl-4-(4-pyridyl)-1-(2H)-phthalazinone, m.p. 173°-174° C.

Workup

  1. temperatureThe mixture was heated
  2. temperatureto reflux
  3. customwhile collecting water in a Dean-Stark trap for 6 hours
  4. additionAdditional methylhydrazine (2.59 mL) was added
  5. temperaturethe mixture was heated
  6. temperatureto reflux for another 5 hours
  7. filtrationthe product was collected by filtration
  8. customThe product was recrystallized from hot methanol

Sources & evidence

ORD record
ord-baf72013f9904f92a0bead29350d084e
Source dataset
uspto-grants-1997_04
Patent number
US05624922

Reaction notes

Loading…