HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid → 1-{4-[5-Bromo-4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid | HCID 596118 | — |
| Reactant | 4-[5-Bromo-4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidine | HCID 67156856 | — |
| Product | 1-{4-[5-Bromo-4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone | HCID 67156400 | — |
Reaction Steps
4-[5-Bromo-4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidine (II-3, 127 mg) is reacted analogously to Example I-81 with [5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetic acid (118 mg). After chromatographic purification, this gives 1-{4-[5-bromo-4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone (52 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07943774B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-d75b1d47eb9449578b9109e441a24501 |
| Source note | uspto-grants-2011_05 |