HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(2-Chloro-5-(trifluoromethyl)phenyl)acetic acid → 2-[2-Chloro-5-(trifluoromethyl)phenyl]-1-{4-[4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(2-Chloro-5-(trifluoromethyl)phenyl)acetic acid | HCID 2778119 | — |
| Reactant | 4-[4-(2-Phenylethyl)-1,3-thiazol-2-yl]piperidine hydrochloride | HCID 67156883 | — |
| Product | 2-[2-Chloro-5-(trifluoromethyl)phenyl]-1-{4-[4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone | HCID 67156418 | — |
Reaction Steps
4-[4-(2-Phenylethyl)-1,3-thiazol-2-yl]piperidine hydrochloride (II-1, 309 mg) is reacted analogously to Example I-63 with [2-chloro-5-(trifluoromethyl)phenyl]acetic acid (262 mg). After chromatographic purification, this gives 2-[2-chloro-5-(trifluoromethyl)phenyl]-1-{4-[4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone (210 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07943774B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-26050bd3fb33456a820f0e06515fd722 |
| Source note | uspto-grants-2011_05 |