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HRID 549958作成日：2026年10月25日

2,5-Bis(trifluoromethyl)benzoyl chloride → [2,5-Bis(trifluoromethyl)phenyl]{4-[4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}methanone

https://huagongshe.com/reaction/549958

反応式

関与物質

役割名称HCID仕込み量
反応物2,5-Bis(trifluoromethyl)benzoyl chlorideHCID 2737812—
反応物4-[4-(2-Phenylethyl)-1,3-thiazol-2-yl]piperidine hydrochlorideHCID 67156883—
生成物[2,5-Bis(trifluoromethyl)phenyl]{4-[4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}methanoneHCID 86642046—

反応手順

4-[4-(2-Phenylethyl)-1,3-thiazol-2-yl]piperidine hydrochloride (II-1, 309 mg) is reacted analogously to Example I-63 with 2,5-bis(trifluoromethyl)benzenecarbonyl chloride (304 mg). After chromatographic purification, this gives [2,5-bis(trifluoromethyl)phenyl]{4-[4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}methanone (282 mg).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07943774B2
出典データセットuspto-grants-2011_05
ORD IDord-e4fca0d484c141c0883e77cbe611e25d
出典メモuspto-grants-2011_05