HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(3,4-Dimethoxyphenyl)propionic acid → 3-(3,4-Dimethoxyphenyl)-1-{4-[4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}propan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(3,4-Dimethoxyphenyl)propionic acid | HCID 75019 | — |
| Reactant | 4-[4-(2-Phenylethyl)-1,3-thiazol-2-yl]piperidine hydrochloride | HCID 67156883 | — |
| Product | 3-(3,4-Dimethoxyphenyl)-1-{4-[4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}propan-1-one | HCID 67156211 | — |
Reaction Steps
4-[4-(2-Phenylethyl)-1,3-thiazol-2-yl]piperidine hydrochloride (II-1, 309 mg) is reacted analogously to Example I-63 with 3-(3,4-dimethoxyphenyl)propanoic acid (231 mg). After chromatographic purification, this gives 3-(3,4-dimethoxyphenyl)-1-{4-[4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}propan-1-one (139 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07943774B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-61d02f19b9354840be4dd85f882f14ae |
| Source note | uspto-grants-2011_05 |