(1,3-Benzothiazol-2-yl)acetic acid → HCID 67156154, compound

HRID 549960Notes

Reaction equation

HRID 549960 reaction equation
Cl.[C:2]1([CH2:8][CH2:9][C:10]2[N:11]=[C:12]([CH:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)[S:13][CH:14]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[S:21]1[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=2[N:23]=[C:22]1[CH2:30][C:31](O)=[O:32]>>[S:21]1[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=2[N:23]=[C:22]1[CH2:30][C:31]([N:18]1[CH2:19][CH2:20][CH:15]([C:12]2[S:13][CH:14]=[C:10]([CH2:9][CH2:8][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[N:11]=2)[CH2:16][CH2:17]1)=[O:32]

Participants

3

Reactant 2

HCID 4961664(1,3-Benzothiazol-2-yl)acetic acidHCID 671568834-[4-(2-Phenylethyl)-1,3-thiazol-2-yl]piperidine hydrochloride

Product 1

HCID 67156154HCID 67156154, compound

Procedure

4-[4-(2-Phenylethyl)-1,3-thiazol-2-yl]piperidine hydrochloride (II-1, 308 mg) is reacted analogously to Example I-63 with 1,3-benzothiazol-2-ylacetic acid (252 mg). After chromatographic purification, this gives 2-(1,3-benzothiazol-2-yl)-1-{4-[4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone (109 mg).

Workup

  1. customAfter chromatographic purification

Sources & evidence

ORD record
ord-174b96ced6fe4f34a33e99a6ea27c6d8
Source dataset
uspto-grants-2011_05
Patent number
US07943774B2

Reaction notes

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