2-(2H-indazol-2-yl)acetic acid → 2-(2H-Indazol-2-yl)-1-{4-[4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone

HRID 549961Notes

Reaction equation

HRID 549961 reaction equation
Cl.[C:2]1([CH2:8][CH2:9][C:10]2[N:11]=[C:12]([CH:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)[S:13][CH:14]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N:21]1[N:22]([CH2:30][C:31](O)=[O:32])[CH:23]=[C:24]2[C:29]=1[CH:28]=[CH:27][CH:26]=[CH:25]2>>[N:21]1[N:22]([CH2:30][C:31]([N:18]2[CH2:19][CH2:20][CH:15]([C:12]3[S:13][CH:14]=[C:10]([CH2:9][CH2:8][C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)[N:11]=3)[CH2:16][CH2:17]2)=[O:32])[CH:23]=[C:24]2[C:29]=1[CH:28]=[CH:27][CH:26]=[CH:25]2

Participants

3

Reactant 2

HCID 122524352-(2H-indazol-2-yl)acetic acidHCID 671568834-[4-(2-Phenylethyl)-1,3-thiazol-2-yl]piperidine hydrochloride

Product 1

HCID 671563292-(2H-Indazol-2-yl)-1-{4-[4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone

Procedure

4-[4-(2-Phenylethyl)-1,3-thiazol-2-yl]piperidine hydrochloride (II-1, 309 mg), prepared according to Process 1.2, is reacted analogously to Example I-63 with 2H-indazol-2-ylacetic acid (194 mg). After chromatographic purification, this gives 2-(2H-indazol-2-yl)-1-{-4-[4-(2-phenylethyl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone (67 mg).

Workup

  1. customAfter chromatographic purification

Sources & evidence

ORD record
ord-ef61bf4b70124998bde1f35fdb50c788
Source dataset
uspto-grants-2011_05
Patent number
US07943774B2

Reaction notes

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