7-Methyl-1-benzothiophene → 5-Bromo-2-chloro-1-(7-methylbenzo[b]thiophen-2-ylmethyl)benzene

HRID 550001Notes

Reaction equation

HRID 550001 reaction equation
[CH3:1][C:2]1[C:7]2[S:8][CH:9]=[CH:10][C:6]=2[CH:5]=[CH:4][CH:3]=1.[Br:11][C:12]1[CH:13]=[CH:14][C:15]([Cl:20])=[C:16]([CH:19]=1)[CH:17]=O>>[Br:11][C:12]1[CH:13]=[CH:14][C:15]([Cl:20])=[C:16]([CH2:17][C:9]2[S:8][C:7]3[C:2]([CH3:1])=[CH:3][CH:4]=[CH:5][C:6]=3[CH:10]=2)[CH:19]=1

Participants

3

Reactant 2

HCID 64285417-Methyl-1-benzothiopheneHCID 106089255-Bromo-2-chlorobenzaldehyde

Product 1

HCID 666081605-Bromo-2-chloro-1-(7-methylbenzo[b]thiophen-2-ylmethyl)benzene

Procedure

7-Methylbenzo[b]thiophene (see Tilak, B. D. Tetrahedron 9 (1960) 76-95)and 5-bromo-2-chlorobenzaldehyde obtained in Reference Example 16-(1) were treated in a manner similar to Reference Example 7 to give the target compound.

Workup

  1. additionwere treated in a manner similar to Reference Example 7
  2. customto give the target compound

Sources & evidence

ORD record
ord-e2255005f6054e308195c545ea2e2a24
Source dataset
uspto-grants-2011_05
Patent number
US07943788B2

Reaction notes

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