Toluene → 2-methyl-4-(3-chloro-4-methoxyphenyl)-1-(2H)-phthalazinone

Participants

Reaction Steps

A mixture of 2-(3-chloro-4-methoxybenzoyl)benzoic acid (10.46 g, 0.036 mol), toluene (50 mL) and methyl hydrazine (2.1 mL) was refluxed in the presence of a Dean Stark trap until the theoretical amount of water had been collected. The reaction mixture was cooled, and the product was collected by filtration to afford 7.42 g (68.7%) of 2-methyl-4-(3-chloro-4-methoxyphenyl)-1-(2H)-phthalazinone, m.p. 195°-195° C. An additional 1.89 g of product was also collected from the filtrate for a total of 9.31 g (86.2%).

Provenance & Evidence