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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 550034Generated: October 26, 2026

2-Thiophenecarboxaldehyde, 5-chloro- → 4-Bromo-2-(5-chloro-2-thienylmethyl)-1-methoxynaphthalene

https://huagongshe.com/reaction/550034

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Thiophenecarboxaldehyde, 5-chloro-HCID 81700—
Reactant2,4-Dibromo-1-methoxynaphthaleneHCID 3572059—
Product4-Bromo-2-(5-chloro-2-thienylmethyl)-1-methoxynaphthaleneHCID 66607824—

Reaction Steps

2,4-Dibromo-1-methoxynaphthalene (see Org. Lett. (2003) 5, 831) and 5-chloro-2-thiophenecarboxaldehyde were treated in a manner similar to Reference Example 1 to give 4-Bromo-2-(5-chloro-2-thienylmethyl)-1-methoxynaphthalene.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07943788B2
Source datasetuspto-grants-2011_05
ORD IDord-2708f7893b0749749ce022132bec25b2
Source noteuspto-grants-2011_05