4-(((tert-Butoxycarbonyl)amino)methyl)benzoic acid → tert-Butyl (4-{[((1R,2S)-2-{[(3aR,4R,9bR)-4-(methoxymethyl)-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinolin-1-yl]carbonyl}cyclohexyl)amino]carbonyl}benzyl)carbamate

Participants

Role	Name	HCID	Charge
Reactant	4-(((tert-Butoxycarbonyl)amino)methyl)benzoic acid	HCID 853605	—
Reactant	(1R,2S)-2-{[(3aR,4R,9bR)-4-(methoxymethyl)-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinolin-1-yl]carbonyl}cyclohexaneamine dihydrochloride	HCID 67150533	—
Product	tert-Butyl (4-{[((1R,2S)-2-{[(3aR,4R,9bR)-4-(methoxymethyl)-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinolin-1-yl]carbonyl}cyclohexyl)amino]carbonyl}benzyl)carbamate	HCID 57846897	—

Reaction Steps

In the same manner as in Reference Example 19 and using 4-{[(tert-butoxycarbonyl)amino]methyl}benzoic acid and (1R,2S)-2-{[(3aR,4R,9bR)-4-(methoxymethyl)-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinolin-1-yl]carbonyl}cyclohexaneamine dihydrochloride, the title compound was synthesized.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07943770B2
Source dataset	uspto-grants-2011_05
ORD ID	ord-9940f0ebcefb480fa215c7e3033738d9
Source note	uspto-grants-2011_05