Potassium Hydroxide → HCID 67199911, compound

Participants

Reaction Steps

To a solution of ethyl 3-bromo-2-piperid-1-yl-5-trifluoromethylbenzoate (830 mg; 1 eq.) in ethanol (30 ml) is added potassium hydroxide (610 mg; 5 eq.). After stirring at reflux for 2 hours, the reaction medium is evaporated to dryness, taken up in water (20 ml) and acidified with 1N HCl. The precipitate is filtered off by suction, washed with water and dried. 600 mg of 3-bromo-2-piperid-1-yl-5-trifluoromethylbenzoic acid are obtained in the form of a white solid.

Provenance & Evidence