Sec-Butylamine → HCID 58617235, compound

Participants

Reaction Conditions

Reaction Steps

The product from Step 3 (0.10 g) was dissolved in DMF (2 ml). Sec-butylamine (0.2 ml) was added and the mixture was refluxed in a sealed tube at 70° C. for 14 hours. The dark coloured reaction mixture was evaporated to give an oil, which was purified by flash column chromatography on silica gel (40-60) in ethyl acetate:hexane 1:1 to give N-sec-butyl-4-chloro-3-(2-chloro-6-fluorophenyl)-1,6-naphthyridin-2-amine as a light yellow gum (0.08 g).

Provenance & Evidence