HCID 58617248, compound → HCID 58617229, compound

HRID 550364Notes

Reaction equation

HRID 550364 reaction equation
[Cl:1][C:2]1[C:11]([C:12]2[C:17]([F:18])=[CH:16][C:15]([F:19])=[CH:14][C:13]=2[F:20])=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][N:8]=2)[N:3]=1>C(N)(C)C>[Cl:1][C:2]1[C:11]([C:12]2[C:17]([F:18])=[CH:16][C:15]([F:19])=[CH:14][C:13]=2[F:20])=[C:10]([NH:3][CH:4]([CH3:9])[CH3:5])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][N:8]=2)[N:3]=1

Participants

3

Reactant 1

HCID 58617248HCID 58617248, compound

Product 1

HCID 58617229HCID 58617229, compoundYield 24.1%

Reagents, catalysts & solvents 1

HCID 6363IsopropylamineSolvent

Conditions

Temperature
60 °C

Procedure

The product from Step 4 (0.070 g) was dissolved in isopropylamine (1.0 ml) and warmed in a sealed tube to 60° C. for 2 hours. The isopropylamine was evaporated and the residue was purified by flash column chromatography on silica gel (40-60) eluting with diethyl ether to give [2-chloro-3-(2,4,6-trifluorophenyl)-[1,5]naphthyridin-4-yl]-isopropylamine as a yellow gum (0.009 g).

Workup

  1. customThe isopropylamine was evaporated
  2. customthe residue was purified by flash column chromatography on silica gel (40-60)
  3. washeluting with diethyl ether

Sources & evidence

ORD record
ord-7931160a2f1d45ccafcbb5918cd74c18
Source dataset
uspto-grants-2011_05
Patent number
US07947679B2

Reaction notes

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