Water → HCID 18440312, compound

HRID 550401Notes

Reaction equation

HRID 550401 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][C:7](=O)[CH2:6][CH2:5]2.[C-:13]#[N:14].[Na+].[C:16](=[O:19])([O-])[O-].[NH4+:20].[NH4+].[OH2:22]>CCO>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][C:7]1([C:13](=[O:22])[NH:14][C:16](=[O:19])[NH:20]1)[CH2:6][CH2:5]2

Participants

6

Reactant 4

HCID 962WaterHCID 8929Sodium CyanideHCID 517111Ammonium CarbonateHCID 27335536-Bromo-2-tetralone

Product 1

HCID 18440312HCID 18440312, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
70 °C

Procedure

A stirred mixture of 6-bromo-2-tetralone (17.6 g, 78.2 mmol), sodium cyanide (9.58 g, 195 mmol), and ammonium carbonate (97.7 g, 1.02 mol) in H2O (100 mL) and EtOH (100 mL) was heated to 70° C. for 3 h, then allowed to cool to ambient temperature. The precipitate was collected by filtration and washed with H2O (5×200 mL). Drying in vacuo afforded the title compound as a pale solid. MS: m/z=297 (M+1).

Workup

  1. temperatureto cool to ambient temperature
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with H2O (5×200 mL)
  4. customDrying in vacuo

Sources & evidence

ORD record
ord-3a9bb89fcf1445faa473203f2e302bbd
Source dataset
uspto-grants-2011_05
Patent number
US07947678B2

Reaction notes

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