3-Methyl-4-[(3-fluorobenzyl)oxy]aniline → 2-{[4-({4-[(3-fluorobenzyl)oxy]-3-methylphenyl}amino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]oxy}ethanol

Beteiligte Stoffe

Reaktionsschritte

The procedure described in Example 1 was repeated using N′-[4-cyano-3-(2-hydroxyethoxy)-1H-pyrazol-5-yl]-N,N-dimethylimidoformamide (2.0 g, 8.96 mmol) and 3-methyl-4-[(3-fluorobenzyl)oxy]aniline (2.5 g, 10.8 mmol) to give the title compound as a white solid (2.12 g, 58%); NMR Spectrum: 2.24 (s, 3H), 3.79 (s, 2H), 4.30 (t, 2H), 5.17 (s, 2H), 7.02 (d, 1H), 7.15 (td, 1H), 7.31 (m, 2H), 7.42 (m, 3H), 7.85 (t, 1H), 8.23 (s, 1H), 8.21 (s, 1H), 8.33 (s, 1H); Mass Spectrum: 410 (MH+).

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