3-Chloro-4-(2-pyridylmethoxy)aniline → 2-[(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-1H-pyrazolo[3,4-d]pyrimidin-3-yl)oxy]ethanol

Beteiligte Stoffe

Reaktionsschritte

The procedure described in Example 1 was repeated using N′-[4-cyano-3-(2-hydroxyethoxy)-1H-pyrazol-5-yl]-N,N-dimethylimidoformamide (1.50 g, 6.72 mmol) and 3-chloro-4-(pyridin-2-ylmethoxy)aniline (1.58 g, 6.72 mmol) to give the title compound as a while solid (2.40 g, 87%); NMR Spectrum: 3.80 (t, 2H), 4.32 (t, 2H), 5.30 (s, 2H), 7.26 (d, 1H), 7.36-7.38 (m, 1H), 7.55-7.59 (m, 2H), 7.86-7.90 (m, 2H), 8.28 (s, 1H), 8.48 (br s, 1H), 8.59 (d, 1H); Mass Spectrum: 413 (MH+).

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