Morpholine → N-{3-chloro-4-[(6-methylpyridin-3-yl)oxy]phenyl}-3-(2-morpholin-4-ylethoxy)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Participants

Reaction Steps

The procedure described in Example 23 was repeated using 3-(2-chloroethoxy)-N-{3-chloro-4-[(6-methylpyridin-3-yl)oxy]phenyl}-1H-pyrazolo[3,4-d]pyrimidin-4-amine (prepared as described in Example 16) and morpholine to give the title compound in 17% yield; NMR Spectrum: 2.45 (s, 3H), 2.50 (hidden by DMSO, 4H), 2.82 (t, 2H), 3.55-3.56 (m, 4H), 4.46 (t, 2H), 7.20 (d, 1H), 7.27 (s, 2H), 7.71 (d, 1H), 8.12 (s, 1H), 8.20 (s, 1H), 8.35 (s, 1H), 8.60 (br s, 1H); Mass Spectrum: 482 (MH+).

Provenance & Evidence