1-Acetylpiperazine → 3-[2-(4-acetylpiperazin-1-yl)ethoxy]-N-{3-chloro-4-[(6-methylpyridin-3-yl)oxy]phenyl}-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Participants

Reaction Steps

The procedure described in Example 23 was repeated using 3-(2-chloroethoxy)-N-{3-chloro-4-[(6-methylpyridin-3-yl)oxy]phenyl}-1H-pyrazolo[3,4-d]pyrimidin-4-amine and N-acetylpiperazine to give the title compound in 32% yield; NMR Spectrum: 1.96 (s, 3H), 2.45 (s, 3H), 2.46-2.53 (m, partially hidden by DMSO, 8H), 2.86 (t, 2H), 4.47 (t, 2H), 6.05 (br s, 1H), 7.20 (d, 1H), 7.26 (br s, 2H), 7.71 (d, 1H), 8.12 (s, 1H), 8.20 (s, 1H), 8.36 (s, 1H); Mass Spectrum: 523 (MH+).

Provenance & Evidence