Potassium Iodide → HCID 11525836, compound

Participants

Reaction Steps

The procedure described in Example 23 was repeated (except that potassium iodide was not used) using 2-{[4-({3-fluoro-4-[(6-methylpyridin-3-yl)oxy]phenyl}amino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]oxy}ethyl methanesulfonate and N-methylpiperazine to give the title compound in 54% yield; NMR Spectrum: 2.11 (s, 3H), 2.44 (s, 8H), 2.08 (t, 2H), 3.31 (hidden by water, 3H), 4.46 (t, 2H), 7.26 (m, 3H), 7.55 (dd, 1H), 8.01 (dd, 1H), 8.24 (d, 1H), 8.36 (s, 1H), 8.60 (br s, 1H); Mass Spectrum: 479 (MH+).

Provenance & Evidence