1-Methylpiperazine → HCID 11533556, compound

Participants

Reaction Steps

The procedure described in Example 23 was repeated using 3-(3-chloropropoxy)-N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine and N-methylpiperazine to give the title compound in 22% yield; NMR Spectrum: 1.95-1.99 (m, 2H), 2.12 (s, 3H), 2.20-2.50 (m, partially hidden by DMSO, 8H), 4.33 (t, 2H), 5.29 (s, 2H), 7.23 (d, 1H), 7.37 (t, 1H), 7.54-7.58 (m, 2H), 7.86-7.89 (m, 2H), 8.27 (s, 1H), 8.44 (br s, 1H), 8.59 (d, 1H); Mass Spectrum: 509 (MH+).

Provenance & Evidence