Piperidin-4-ol → HCID 44455293, compound

Participants

Reaction Steps

The procedure described in Example 55 was repeated using 2-{[4-({4-[(3-fluorobenzyl)oxy]-3-methoxyphenyl}amino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]oxy}ethyl methanesulfonate and 4-hydroxypiperidine to give the title compound in 46% yield; NMR Spectrum: 1.36 (d, 2H), 1.69 (d, 2H), 2.18 (t, 2H), 2.78 (m, 4H), 3.80 (s, 3H), 4.42 (t, 2H), 4.55 (d, 1H), 5.11 (s, 2H), 7.02 (d, 1H), 7.16 (m, 2H), 7.30 (m, 2H), 7.36 (d, 1H), 7.44 (q, 1H), 8.25 (s, 1H), 8.45 (s, 1H); Mass Spectrum: 509 (MH+).

Provenance & Evidence