1-Methylpiperazine → HCID 11547702, compound

Participants

Reaction Steps

The procedure described in Example 55 was repeated using 2-{[4-({4-[(3-fluorobenzyl)oxy]-3-methylphenyl}amino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]oxy}ethyl methanesulfonate (prepared as described in Example 21) and N-methylpiperazine to give the title compound in 23% yield; NMR Spectrum: 2.09 (s, 3H), 2.28 (s, 3H), 2.50 (s, 4H), 2.77 (t, 2H), 4.42 (t, 2H), 5.16 (s, 2H), 7.00 (d, 1H), 7.16 (td, 1H), 7.31 (m, 2H), 7.43 (m, 3H), 8.16 (s, 1H), 8.24 (s, 1H); Mass Spectrum: 492 (MH+).

Provenance & Evidence