1-Methylpiperazine → HCID 11656076, compound

Participants

Reaction Steps

The procedure described in Example 55 was repeated using 2-[(4-{[3-ethyl-4-(pyridin-2-ylmethoxy)phenyl]amino}-1H-pyrazolo[3,4-d]pyrimidin-3-yl)oxy]ethyl methanesulfonate (prepared as described in Example 19) and N-methylpiperazine to give the title compound in 44% yield; NMR Spectrum: 1.20 (t, 3H), 2.10 (s, 3H), 2.20-2.35 (m, 4H), 2.40-2.55 (m, 4H), 2.65 (q, 2H), 2.77 (t, 2H), 4.40 (t, 2H), 5.20 (s, 2H), 7.01 (d, 1H), 7.34-7.40 (m, 2H), 7.48-7.54 (m, 2H), 7.85 (td, 1H), 8.23 (s, 1H), 8.26 (s, 1H), 8.59 (d, 1H); Mass Spectrum: 489 (MH+).

Provenance & Evidence